Lewis lung carcinoma

Cancers

Lewis lung carcinoma is a hypermutated Kras/Nras-mutant cancer that arose spontaneously as an epidermoid carcinoma in the lung of a C57BL mouse. Discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute, it became one of the first transplantable tumors. It has mutations affecting cancer genes and pathways, with Cdkn2a and Cdkn2b deleted. The supplied data suggest similarity to human lung adenocarcinoma.

The picture on this card was made with AI. It is an illustration, not a real photo of the subject.

Origin: Spontaneously developed in the lung of a C57BL mouse
Discovery: Discovered in 1951 by Dr. Margaret Lewis
Cancer type: Hypermutated Kras/Nras-mutant cancer

Sources and credits

Article: Lewis lung carcinoma (English Wikipedia)
Wikidata: Q6537255
Text: Card text is adapted from the English Wikipedia article by an automated summary. Wikipedia content is available under CC BY-SA 4.0; see the article history for its contributors. CC BY-SA 4.0 · Article history and contributors
Illustration: AI-generated illustration. Not a photograph or documentary image. (model: gpt-image-2.5-flare)
Popularity: 4 median daily views (Wikimedia Pageviews API (all-access, user agent))

Kosmora is not affiliated with or endorsed by the Wikimedia Foundation.