OSBPL2

Genetics and Molecular Biology

OSBPL2 is a human protein-coding gene that encodes oxysterol-binding protein-related protein 2. The protein belongs to the oxysterol-binding protein family of intracellular lipid receptors. Unlike most family members, the encoded protein contains only a conserved C-terminal OSBP-like sterol-binding domain. In vitro, it binds strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but not to 25-hydroxycholesterol. It associates with the Golgi apparatus, and transcript variants encode different isoforms.

Gene product: Oxysterol-binding protein-related protein 2
Protein family: Oxysterol-binding protein family
Cellular association: Golgi apparatus

Sources and credits

Article: OSBPL2 (English Wikipedia)
Wikidata: Q18034852
Text: Card text is adapted from the English Wikipedia article by an automated summary. Wikipedia content is available under CC BY-SA 4.0; see the article history for its contributors. CC BY-SA 4.0 · Article history and contributors
Illustration: By Deposition authors: Wang, H., Dong, J.Q., Wang, J., Wu, J.W.; visualization author: User:Astrojan. CC BY-SA 4.0 · File page on Wikimedia Commons
Deposition authors: Wang, H., Dong, J.Q., Wang, J., Wu, J.W.; visualization author: User:Astrojan, http://www.rcsb.org/structure/5zm8
Modifications: Resized and converted to WebP
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