Cyclopamine

Chemical Compounds

Cyclopamine, also called 11-deoxojervine, is a naturally occurring steroidal alkaloid and a teratogenic component of corn lily (Veratrum californicum). Consumption of the plant during gestation has been shown to cause birth defects in offspring, including cyclopia. The molecule was named for this effect after cycloptic lambs were observed among Idaho herds in 1957. Cyclopamine interrupts the sonic hedgehog signalling pathway, which is important in early development.

Chemical class: Naturally occurring steroidal alkaloid
Natural source: Corn lily (Veratrum californicum)
Biological action: Interrupts sonic hedgehog signalling

Sources and credits

Article: Cyclopamine (English Wikipedia)
Wikidata: Q3271319
Text: Card text is adapted from the English Wikipedia article by an automated summary. Wikipedia content is available under CC BY-SA 4.0; see the article history for its contributors. CC BY-SA 4.0 · Article history and contributors
Illustration: By Fvasconcellos. Public domain · File page on Wikimedia Commons
Fvasconcellos, Own work
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