Acriflavine resistance protein family

Proteins and Enzymes

The acriflavine resistance protein family includes bacterial transmembrane transport proteins involved in multidrug efflux. In Escherichia coli, acrA and acrB encode a system believed to protect the bacterium from hydrophobic inhibitors. AcrB is powered by proton-motive force and has broad substrate specificity, including antibiotics, disinfectants, dyes, detergents and simple solvents. The ligand-free AcrB transporter is a homotrimer whose subunits each contain 12 transmembrane helices and large periplasmic domains.

System role: Multidrug efflux system in E. coli
Energy source: Proton-motive force
Structure: Homotrimer, 110 kDa per subunit

Sources and credits

Article: Acriflavine resistance protein family (English Wikipedia)
Wikidata: Q24768910
Text: Card text is adapted from the English Wikipedia article by an automated summary. Wikipedia content is available under CC BY-SA 4.0; see the article history for its contributors. CC BY-SA 4.0 · Article history and contributors
Illustration: By Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute. Public domain · File page on Wikimedia Commons
Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute, https://www.ebi.ac.uk/pdbe/static/entry/1oye_deposited_chain_front_image-800x800.png, displayed on https://www.ebi.ac.uk/pdbe/entry/pdb/1oye
Modifications: Resized and converted to WebP
Popularity: 1 median daily views (Wikimedia Pageviews API (all-access, user agent))

Kosmora is not affiliated with or endorsed by the Wikimedia Foundation.